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Mescaline is still used in indigenous ceremony, though there is concern surrounding the sustainability of the peyote cactus due to its slow growth cycle and declining abundance. In the 19th century, when northern and eastern tribes were forcibly pushed out of their lands in America by European colonialists, the use of peyote became more widespread as these tribes came into contact with those in the Southwest-one of the few places in the U.S. Indigenous populations have long held mescaline as a sacred medicine in spiritual ritual and healing ceremonies.
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The mystical experiences imparted by mescaline pre-date Huxley by millenia evidence of mescaline use, in its various forms, dates as far back as 5,700 years. He will be wiser but less sure, happier but less self-satisfied, humbler in acknowledging his ignorance yet better equipped to understand the relationship of words to things, of systematic reasoning to the unfathomable mystery which it tries, forever vainly, to comprehend.” “The man who comes back through the Door in the Wall will never be quite the same as the man who went out.